Palmitoyl-protein thioesterase 1
WebDec 20, 2005 · Palmitoyl-protein thioesterase-1 (PPT1), a lysosomal enzyme, cleaves thioester linkages in S-acylated proteins and removes palmitate residues facilitating the degradation of these proteins. Thus, inactivating mutations in the PPT1 gene cause infantile neuronal ceroid lipofuscinosis (INCL), a devastating neurodegenerative storage disorder … WebApr 18, 2000 · Mutations in palmitoyl-protein thioesterase 1 (PPT1), a lysosomal enzyme that removes fatty acyl groups from cysteine residues in modified proteins, cause the …
Palmitoyl-protein thioesterase 1
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WebJan 23, 2024 · The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc. Natl Acad. Sci. USA 97 , 4573–4578 (2000). WebNov 9, 2013 · One of the upregulated spots was palmitoyl-protein thioesterase 1 (PPT1), a lipoprotein metabolizing related enzyme localized to Sertoli cells. In a Sertoli-cell line cultured in a high-fat supplemented medium, PPT1 abundance was accompanied by increases in the endocytic vesicle-associated protein, clathrin, and decreases in the tight …
WebOliver Oswald is an academic researcher from BASF Plant Science. The author has contributed to research in topic(s): Nucleic acid & Nucleic acid methods. The author has an hindex of 7, co-authored 32 publication(s) receiving 149 citation(s). Previous affiliations of Oliver Oswald include Max Planck Society. WebPalmitoyl-protein thioesterase (PPT; EC 3.1.2.22) is a small glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins.PPT is thought to be …
WebPalmitoyl-protein thioesterase 1 removes certain fats called long-chain fatty acids from specific proteins, typically a fatty acid called palmitate. Removing these fatty acids helps break the proteins down when they are no longer needed. Palmitoyl-protein thioesterase 1 is also thought to be involved in a variety of other cell functions, such as WebPalmitoyl Protein Thioesterase. Palmitoyl protein thioesterase 1 (PPT1) and PPT2 are primarily located in lysosomes and catalyze depalmitoylation during protein degradation …
WebThe synthetic substrate for palmitoyl-protein thioesterase 1 (PPT1) is 4-methylumbelliferyl-6-thiopalmitoyl-beta-glucoside. The leukocytes are homogenized and combined with …
WebSynonyms: Palmitoyl-protein thioesterase 1(PPT-1), Palmitoyl-protein hydrolase 1 UniProt P50897 Pathways SARS-CoV-2 Protein Interactome; You are here: Homepage ELISA Kits PPT1 ELISA Kits PPT1 ELISA Kit (ABIN5593926) Service. Contact ... heather dyer waterWebJul 1, 2009 · In addition to the implication of cathepsins in apoptosis, another lysosomal protease, palmitoyl protein thioesterase 1 (PPT1; EC 3.1.2.22) might also be involved in cell death signaling. Overexpression of PPT1 could protect human neuroblastoma cells against C 2 -ceramide-induced caspase-3 activation and DNA fragmentation [22]. heather dyer mdWebMay 4, 2000 · Palmitoyl-protein thioesterase-1 (PPT1) is a newly described lysosomal enzyme that hydrolyzes long chain fatty acids from lipid-modified cysteine residues in proteins. Deficiency in this enzyme results in a severe neurodegenerative storage disorder, infantile neuronal ceroid lipofuscinosis. heather dyer sbvmwdWebJul 3, 2024 · 3.1 Palmitoyl protein thioesterase-1 was significantly increased in enzymatic activity in schizophrenia patients. Palmitoyl-protein thioesterase 1 was weakly correlated with functional magnetic resonance imaging in specific brain regions, 28 and the PPT1 gene was analysed as one of the candidate genes showing potential for a blood-based marker … movie being shot in phillyWebItem Recombinant Human Palmitoyl-Protein Thioesterase 1/PPT1 (C-6His) Company Bon Opus Biosciences; Price Pricing Info Supplier Page View Company Product Page; Catalog … heather dyer uspsPalmitoyl protein hydrolase/thioesterases is an enzyme (EC 3.1.2.22) that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. It catalyzes the reaction palmitoyl[protein] + H2O palmitate + protein movie being filmed in washington dcWebAug 29, 2024 · Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration Front Synaptic Neurosci. 2024 Aug 29;11:25. doi: 10.3389 ... α/β hydrolase … heather dyer stamey